Peptide Lexicon

Ipamorelin

Ipamorelin in the T&T Supplies peptide lexicon: research reference with mechanism, reported effects, limitations and literature data. Evidence grade C+.

Mechanism

Selective GHRH receptor agonist. GHSR-1a (ghrelin receptor) agonist → pulsatile GH release from pituitary. Highly selective. No ACTH, cortisol, or prolactin stimulation at standard doses. Cleanest GHRP.

Reported effects

Clean GH stimulation. Improved deep sleep. Recovery enhancement. Lean mass support. Better tolerated than GHRP-2/6.

Limitations

Endogenous GH is already high in young adults, so the added effect may be marginal. Potential GH receptor downregulation. Water retention possible. Not FDA approved.

Literature data

Dosage (literature)

100-300mcg per injection. 1-3×/day. Most useful pre-bed

Timing

Pre-bed (maximize natural GH pulse). Can stack with CJC-1295 no-DAC

Cycling

12-week cycles, 4-6 weeks off

CJC-1295 + IPA in the shop

Information for research purposes only.