Peptide Lexicon

Pinealon

Pinealon in the T&T Supplies peptide lexicon: research reference with mechanism, reported effects, limitations and literature data. Evidence grade C.

Mechanism

Synthetic tripeptide (Glu-Asp-Arg) derived from the pineal gland. Claimed to regulate melatonin secretion rhythm. Neuroprotective against oxidative stress. Potentially modulates DNA methylation patterns in neurons. Anti-apoptotic in neuronal cell lines.

Reported effects

Potential sleep quality improvement. Neuroprotective effects in animal models. Claimed cognitive enhancement.

Limitations

All evidence from single Russian research group (Khavinson) — significant conflict of interest. No independent replication. Human data limited to elderly. Mechanism insufficiently characterized.

Literature data

Dosage (literature)

5-10mg course over 10 days

Timing

Evening for circadian effects

Cycling

10-day courses 2-3× per year

Information for research purposes only.