Peptide Lexicon

MOTS-C

MOTS-C in the T&T Supplies peptide lexicon: research reference with mechanism, reported effects, limitations and literature data. Evidence grade C+.

Mechanism

Peptide encoded in mitochondrial genome. Acts as metabolic regulator. Activates AMPK. Inhibits AICAR → folate cycle disruption → metabolic reprogramming. Improves glucose uptake independent of insulin.

Reported effects

Improved insulin sensitivity. Enhanced exercise capacity and metabolic efficiency. Anti-obesity effects. Potential longevity effects. Exercise-mimicking properties.

Limitations

Most data animal studies. Human trial data limited to one small RCT. Age-related benefit unclear in young healthy subjects. Expensive.

Literature data

Dosage (literature)

5-10mg subcut 2-3×/week

Timing

Morning or pre-workout

Cycling

4-8 week cycles

Information for research purposes only.