Peptide Lexicon
Melanotan-1
Melanotan-1 in the T&T Supplies peptide lexicon: research reference with mechanism, reported effects, limitations and literature data. Evidence grade A-.
Mechanism
Synthetic α-MSH analogue with MC1R selectivity. MC1R agonism → tyrosinase upregulation → eumelanin synthesis. UV activation required to convert precursors to visible pigment.
Reported effects
Deep even tan. Photoprotection. Visually reduces PIE by contrast. EMA-approved safety data. Lower systemic effects vs MT-2.
Limitations
Nausea during loading (reduced by microdosing). Mole changes — document before starting. UV >3 required for activation. MC4R spillover at high doses.
Literature data
- Dosage (literature)
- Loading: 500mcg/day × 14 days. Maintenance: 250-500mcg E2-3D + UV
- Timing
- Evening — sleep through initial nausea
- Cycling
- Loading → Maintenance. No continuous loading
Information for research purposes only.