Peptide Lexicon

KPV

KPV in the T&T Supplies peptide lexicon: research reference with mechanism, reported effects, limitations and literature data. Evidence grade C+.

Mechanism

C-terminal tripeptide fragment of α-MSH. Inhibits NF-κB signalling. Reduces TNF-α, IL-1β, IL-6 production. Activates MC1R and MC3R locally (anti-inflammatory, not pigmentation). Promotes intestinal epithelial healing.

Reported effects

Potent anti-inflammatory for gut, skin, and systemic use. Oral bioavailability for GI-specific effects. No melanocortin pigmentation effects. Excellent safety profile. Can be combined with BPC-157 for enhanced GI healing.

Limitations

Limited human clinical trial data. Research peptide status. Very short half-life requires frequent dosing or oral route.

Literature data

Dosage (literature)

500mcg–2mg subcut or 1-5mg oral per day

Timing

Any time. Oral pre-meals for GI effects

Cycling

Continuous low-dose or acute 4-week protocols

Information for research purposes only.